I have not used them out of a handgun (yet), but I have used the 240 grain .44 cal version in my muzzleloader (just the bullet obviously). Velocities out of the muzzleloader are a little higher than out of a revolver, but I was satisfied with the results on game.
I have since switched over to the 240 grain Hornady XTPs because they are cheaper and give the same accuracy and performance.