Anything .243+ will kill any deer at 300yds. Accuracy is about repeatabilility: hitting the same spot everytime. I would focus on a rifle that is accurate; caliber would be a secondary concern.
My go-to is the 7MM REM. MAG.
I've had a variety of center fire rifle calibers over the years. I have not found any caliber that covers all the gaps quite like the Big7.
There is a reason for the world-wide following since it was announced and Remington introduced it in 1962.
BAD TO THE BONE!