I have shot a lot of deer with 90 grains of loose pyrodex and solid lead 350-grain bullets, like dozens of them. The only one without an exit wound was shot through longways, and the bullet hit between the neck and shoulder, went all the way through the deer longways, and was stuck under the skin on the back ham. I doubt if there is a muzzleloader capable of burning 150 grains of powder. A lot of it will be wasted. The loose stuff is much better than the pellets, IMO.I don't know the velocity difference in 2 vs 3 pyrodex pellets but this year I'm going to start using 3 because I have not seen an exit wound in the last several deer I shot with 2.