New weight-loss prescriptions: Tirzepitides/Semaglutides?

[BeerThirty]

It seems as if there are several new and surprisingly very effective weight-loss prescriptions coming to the market. I keep seeing more and more success stories and advertising for the likes of Wegovy, Eli Lilly, Ozempic, etc... These all seem to be advertising average weight-loss of 15% or more, with 20-25% observed with stronger doses.

Curious as to everyones' thoughts on these and, better yet, if anyone with experience on these drugs would be willing to share?

I've been a big man my whole life and while I am slowly making progress, but I am also entertaining the idea of one of these drugs. What concerns me is that they are relatively new to market, although the Eli Lilly one was approved by the FDA. As well, I understand the general lack of insurance coverage makes this very expensive, $1,000+/month with no coverage, but I have not seen any pricing on how much it costs if it is covered.

P.S. seems like a good investment opportunity too, imo...

Happy chatting

 

[menhadenman]

My understanding is that more of the weight loss is from decreased lean mass (bones/muscle) over traditional weight loss methods (diet/exercise). My father in law is on ozempic to help with his diabetes but still has a god awful diet.

To each his own but I’ve got a lot of trouble trusting pharma and govt after the COVID debacle.

I dropped about 45 lbs last year doing a bit of carnivore and cutting way back on bad carbs and those mighty tasty microbrews. Check out the free ap chronometer. Kind of a pain and my younger self would tease me for tracking my diet so closely but we’re all getting old sooner or later. I’m back in pants I couldn’t have worn since 1994.

Good luck either way!

 

[livinoutdoors]

This is the absolute truth and there is no getting around it. All these drugs or the similar weight loss surgeries do are restrict you from eating, either by shrinking your stomach or suppressing your appetite. Thats it. You dont need drugs to stop eating too much of the wrong foods. Being active and eating good healthy food is the answer.

 

[BeerThirty]

This is the absolute truth and there is no getting around it. All these drugs or the similar weight loss surgeries do are restrict you from eating, either by shrinking your stomach or suppressing your appetite. Thats it. You dont need drugs to stop eating too much of the wrong foods. Being active and eating good healthy food is the answer.

Agree 100%. But it is ALWAYS easier said than done.

 

[menhadenman]

If you maintain a ~500 calorie daily deficit on average and keep both carbs and alcohol at less than 10% (each) of your total calories you’d be surprised how quick you’ll dump body fat.

I have trouble cutting back on eating so it forces me to get in more physical activity. I’m closing in on 50 and was having health issues that guys in their 60s have. A few months of getting to where I should be made all that trouble go away.

Good luck brother it’s a tough start but you’ll be in a better spot and enjoy life much more when you get rolling.

 

[livinoutdoors]

Agree 100%. But it is ALWAYS easier said than done.

Thats also the truth. It can be done if you want it bad enough. You just gotta stick to it is all. It aint any fun i get it, but this other stuff aint the way i promise.

 

[jbogg]

I will echo what’s been said above, In addition to the high cost, once someone discontinues the drug they quickly regain the weight they have lost and then some.

A low carb diet works wonders. We’ve been doing it for almost a year, and within a few weeks the weight starts falling off quickly. It’s counter intuitive to think that you can lose weight on a high fat diet, but it’s a fact. And if you’re worried about feeling hungry all the time, you won’t be. Once your body adjusts to a low-carb, high fat diet, you will feel very satiated. For hundreds of thousands of years we were primarily hunter gatherers, and our bodies were used to going extended times in between meals. Once your body gets fat adapted you will see what I mean.

My brother in law went from 270 to 230 in six months, and is constantly telling everyone how easy it was to do.

 

[SarahFair]

I know someone on Ozempic for diabetes and they dropped some weight, but its because they have little to no appetite.
When they do eat they eat like garbage, wont bother to learn anything about it proper nutrition, and just doesnt believe their diabetes (or any other of their ailments) is caused by what they are sticking in their mouth.
The Ozempic is also causing them to have bad bouts of vomiting and diarrhea.
I dont know if there is a correlation with their horroble diet and the medication, or if it's just not agreeable for some people.

I know another person that had to get off it because it was doing the same thing to them, but Im not sure of their diet.


I was on adhd medication for a few years before I decided to quit taking it. It suppressed my appetite, but when I came off it my metabolism was very screwed up for awhile, but proper diet and exercise fixed me right up.
So if you go the route of suppressants, keep that in mind.. the weight will come back.

 

[oldfella1962]

My understanding is that more of the weight loss is from decreased lean mass (bones/muscle) over traditional weight loss methods (diet/exercise). My father in law is on ozempic to help with his diabetes but still has a god awful diet.

To each his own but I’ve got a lot of trouble trusting pharma and govt after the COVID debacle.

I dropped about 45 lbs last year doing a bit of carnivore and cutting way back on bad carbs and those mighty tasty microbrews. Check out the free ap chronometer. Kind of a pain and my younger self would tease me for tracking my diet so closely but we’re all getting old sooner or later. I’m back in pants I couldn’t have worn since 1994.

Good luck either way!

That's what I was wondering! If these medications make you lose "weight" is that just water weight or worse - lean body mass weight? Not nit-picking but I did a career in the military - I pretty much had to know the basic science behind weight/fitness/body composition/metabolism/etcetera or be out of a job.

 

[hunt n duck]

I have been reading articles about Ozempic and Wegovy and the bad side effects they have been causing. Things like stomach and intestinal issues. I would do so serious research before I tried them.

 

[menhadenman]

That's what I was wondering! If these medications make you lose "weight" is that just water weight or worse - lean body mass weight? Not nit-picking but I did a career in the military - I pretty much had to know the basic science behind weight/fitness/body composition/metabolism/etcetera or be out of a job.

Ozempic May Make Your Muscles and Bones Weaker

Weight loss medications like Ozempic and Wegovy can help people drop pounds quickly, but they can also cause a rapid loss of muscle mass and bone density unless lifestyle changes are made.

www.healthline.com

 

[Jim Baker]

Throw a little exercise into whatever diet method you use. I lost 20 lbs in 12 months by cutting out all fried foods. We don't have any cooking oil in the house. Took a month or so to get use to the broiled or boiled diet.

 

[oldfella1962]

I will echo what’s been said above, In addition to the high cost, once someone discontinues the drug they quickly regain the weight they have lost and then some.

A low carb diet works wonders. We’ve been doing it for almost a year, and within a few weeks the weight starts falling off quickly. It’s counter intuitive to think that you can lose weight on a high fat diet, but it’s a fact. And if you’re worried about feeling hungry all the time, you won’t be. Once your body adjusts to a low-carb, high fat diet, you will feel very satiated. For hundreds of thousands of years we were primarily hunter gatherers, and our bodies were used to going extended times in between meals. Once your body gets fat adapted you will see what I mean.

My brother in law went from 270 to 230 in six months, and is constantly telling everyone how easy it was to do.

It can be easy for some people, and very hard for others, but most people fall about in the middle. But what you said is true - humans evolved over hundreds of thousands of years, and no matter what type of food sources we relied on - as we spread out into different climates with different critters and plants - food was always pretty scarce and we had to work pretty hard to get it. Our bodies can adapt to pretty much any type of diet, but being sedentary and eating too much too often was never part of human evolution. The more we deviate from the original "game plan" the more medical problems we will have.

 

[elfiii]

Agree 100%. But it is ALWAYS easier said than done.

Yep. That's why you just got to cowboy up. It's all about calories in/calories out and there's good calories and bad calories.

Diet and exercise are the old reliables. Stay away from them pills!

 

[MudDucker]

I've seen some bad juju from weight loss drugs in the past.

 

[Dustin Pate]

I know a couple folks using the different versions and it has been life changing for them. They have embraced the whole lifestyle change with it including better eating habits. Both had some minor nausea when they started, but little to no side effects since.

 

[Mars]

To lose weight and keep it off takes a lifestyle change and a shift in mindset.

A small chamge that I've seem make a noticable difference in several men I know is drinking nothing but water. No sweat tea, sodas, beer, or coffee with sugar.

 

[transfixer]

I know a couple people that were taking the semaglutide (Ozempic?) they did lose weight, but also lost a LOT of muscle mass, to the point they looked sickly , and there are intestinal issues for some people, people that have taken it and stopped , regained the weight after stopping ,

There is no magic bullet, those drugs were designed for diabetics, not weight loss, but Big Pharma will not look a gift horse in the mouth! they will sell it and are pushing doctors and clinics to prescribe it,, just like they were and still are pushing the vaccines !

Why would you want to trust them ?

the only way to lose weight and keep it off is to alter your lifestyle/diet, cut out any food item that has over 3 or 4% sugar content, nothing that has added sugar ! if you do that you will notice a difference in the way you feel within 2 weeks ! cut out all "white" foods, no white bread , no potatoes, no pasta,

2019 or so I was over 300lbs, I did the above and lost down to 223lbs , currently weigh 235-240lbs because I started back on testosterone replacement therapy which will cause you to add muscle back and retain a little more fluid in the process, but feel as good as I did in my 40's, and I'll be 63 in June

 

[Mauser]

Since February of last year I’ve went from 297 to 225. I was on mounjaro, but new insurance wont cover it this year. My wife has also lost 70-80 lbs in that same time frame. Side effects were not bad for us. Some issues with diarrhea and constipation but minimal.

 

[dwhee87]

My GF works in a hospital, and says a lot of the nurses she's around are on ozempic for weight loss. She said she can tell who is, by their sickly look & greyish skin tone.

Get active, cut carbs and alcohol, stop eating processed foods. You'll be surprised how fast you'll drop pounds, and feel way better. One of our members on here I know dropped close to 45 pounds in 6 months by walking 5-6 miles daily and improving his diet.